Ahn, Hong Ryul Lee, Hee Ju Kim, Kyung-A Kim, Chul Young Nho, Chu Won Jang, Holim Pan, Cheol-Ho Lee, Chang Yong Jung, Sang Hoon 2024-01-20T10:31:09Z 2024-01-20T10:31:09Z 2021-09-05 2014-02-12 0021-8561 https://pubs.kist.re.kr/handle/201004/127092 We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against N-methyl-D-aspartate-induced damage to the rat retinas. In vitro, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic proteins and mRNA level induced by 1-buthionine-(S,R)-sulfoximine combined with glutamate, reduced reactive oxygen species production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and 3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both in vitro and in vivo studies. Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food. English AMER CHEMICAL SOC GANGLION-CELL DEATH OPTIC-NERVE CRUSH LIPID-PEROXIDATION CHICORIC ACID ANTIOXIDANT APOPTOSIS GLAUCOMA INDUCTION NMDA EXPRESSION Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage Article 10.1021/jf4046232 1 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.6, pp.1310 - 1323 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62 6 1310 1323 scie scopus 000331343700014 2-s2.0-84894122362 Agriculture, Multidisciplinary Chemistry, Applied Food Science & Technology Agriculture Chemistry Food Science & Technology Article GANGLION-CELL DEATH OPTIC-NERVE CRUSH LIPID-PEROXIDATION CHICORIC ACID ANTIOXIDANT APOPTOSIS GLAUCOMA INDUCTION NMDA EXPRESSION Crepidiastrum denticulatum chicoric acid glaucoma neuroprotection RGC-5