Cho, Yong Woo Kim, Sang Yoon Kwon, Ick Chan Kim, In-San 2024-01-20T10:31:14Z 2024-01-20T10:31:14Z 2021-09-05 2014-02-10 0168-3659 https://pubs.kist.re.kr/handle/201004/127096 Tumors begin with a single cell, but as each tumor grows and evolves, it becomes a wide collection of clones that display remarkable heterogeneity in phenotypic features, which has posed a big challenge to current targeted anticancer therapy. Intra-and inter-tumoral heterogeneity is attributable in part to genetic mutations but also to adaptation and evolution of tumors to heterogeneity in tumor microenvironments. If tumors are viewed not only as a disease but also as a complex adaptive system(CAS), tumors should be treated as such and a more systemic approach is needed. Some of many tumors therapeutic strategies are discussed here from a view of a tumor as CAS, which can be collectively called a complex adaptive therapeutic strategy (CATS). The central theme of CATS is based on three intermediate concepts: i) disruption of artifacts, ii) disruption of connections, and iii) reprogramming of cancer-immune dynamics. Each strategy presented here is a piece of the puzzle for CATS. Although each piece by itself may be neither novel nor profound, an assembled puzzle could be a novel and innovative cancer therapeutic strategy. (C) 2013 Elsevier B.V. All rights reserved. English ELSEVIER DRUG HETEROGENEITY PENETRATION ULTRASOUND EFFICACY DELIVERY Complex adaptive therapeutic strategy (CATS) for cancer Article 10.1016/j.jconrel.2013.12.017 1 JOURNAL OF CONTROLLED RELEASE, v.175, pp.43 - 47 JOURNAL OF CONTROLLED RELEASE 175 43 47 scie scopus 000330121200006 2-s2.0-84891773419 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article DRUG HETEROGENEITY PENETRATION ULTRASOUND EFFICACY DELIVERY Tumor heterogeneity Complex adaptive system (CAS) Induced phenotype Tumor network Cancer immunotherapy Nanoparticle