Heiney, Shane A. Kim, Jinsook Augustine, George J. Medina, Javier F. 2024-01-20T10:31:21Z 2024-01-20T10:31:21Z 2022-01-10 2014-02-05 0270-6474 https://pubs.kist.re.kr/handle/201004/127102 Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking. We used an optogenetic approach in awake mice to show for the first time that transiently suppressing spontaneous activity in a population of PCs is sufficient to cause discrete movements that can be systematically modulated in size, speed, and timing depending on how much and how long PC firing is suppressed. We further demonstrate that this fine control of movement kinematics is mediated by a graded disinhibition of target neurons in the deep cerebellar nuclei. Our results prove a long-standing model of cerebellar function and provide the first demonstration that suppression of inhibitory signals can act as a powerful mechanism for the precise control of behavior. English SOC NEUROSCIENCE SIMPLE-SPIKE ACTIVITY CEREBELLAR NUCLEI MOTOR OUTPUT ACQUISITION DISCHARGE RESPONSES MONKEY COORDINATION POPULATIONS MODULATION Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity Article 10.1523/JNEUROSCI.4547-13.2014 1 JOURNAL OF NEUROSCIENCE, v.34, no.6, pp.2321 - 2330 JOURNAL OF NEUROSCIENCE 34 6 2321 2330 scie scopus 000331455200029 2-s2.0-84893474439 Neurosciences Neurosciences & Neurology Article SIMPLE-SPIKE ACTIVITY CEREBELLAR NUCLEI MOTOR OUTPUT ACQUISITION DISCHARGE RESPONSES MONKEY COORDINATION POPULATIONS MODULATION basket cells disinhibition eyeblink forward model inverse model molecular layer interneurons