Druckmann, Shaul Feng, Linqing Lee, Bokyoung Yook, Chaehyun Zhao, Ting Magee, Jeffrey C. Kim, Jinhyun 2024-01-20T10:31:22Z 2024-01-20T10:31:22Z 2022-01-10 2014-02-05 0896-6273 https://pubs.kist.re.kr/handle/201004/127103 The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity. English CELL PRESS CA1 PYRAMIDAL NEURONS IN-VIVO CORTICAL-NEURONS RAT DENDRITES CELLS INTEGRATION MULTIPLE INPUTS ORGANIZATION Structured Synaptic Connectivity between Hippocampal Regions Article 10.1016/j.neuron.2013.11.026 1 NEURON, v.81, no.3, pp.629 - 640 NEURON 81 3 629 640 scie scopus 000330965500016 2-s2.0-84895165380 Neurosciences Neurosciences & Neurology Article CA1 PYRAMIDAL NEURONS IN-VIVO CORTICAL-NEURONS RAT DENDRITES CELLS INTEGRATION MULTIPLE INPUTS ORGANIZATION