Shin, Jung Hwal Kim, Guk Bae Lee, Eun Joo An, Taechang Shin, Kumjae Lee, Seung Eun Choi, WooSeok Lee, Sukchan Latchoumane, Charles Shin, Hee-Sup Lim, Geunbae 2024-01-20T10:31:43Z 2024-01-20T10:31:43Z 2022-01-25 2014-02 2192-2640 https://pubs.kist.re.kr/handle/201004/127120 Microelectrodes are widely used for monitoring neural activities in various neurobiological studies. The size of the neural electrode is an important factor in determining the signal-to-noise ratio (SNR) of recorded neural signals and, thereby, the recording sensitivity. Here, it is demonstrated that commercial tungsten microelectrodes can be modified with carbon nanotubes (CNTs), resulting in a highly sensitive recording ability. The impedance with the respect to surface area of the CNT-modified electrodes (CNEs) is much less than that of tungsten microelectrodes because of their large electrochemical surface area (ESA). In addition, the noise level of neural signals recorded by CNEs is significantly less. Thus, the SNR is greater than that obtained using tungsten microelectrodes. Importantly, when applied in a mouse brain in vivo, the CNEs can detect action potentials five times more efficiently than tungsten microelectrodes. This technique provides a significant advance in the recording of neural signals, especially in brain regions with sparse neuronal densities. English WILEY Carbon- Nanotube- Modifi ed Electrodes for Highly Effi cient Acute Neural Recording Article 10.1002/adhm.201300183 1 ADVANCED HEALTHCARE MATERIALS, v.3, no.2, pp.245 - 252 ADVANCED HEALTHCARE MATERIALS 3 2 245 252 N scie scopus 000331949000011 2-s2.0-84893478887 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Article CONDUCTING-POLYMER NANOTUBES ATOMIC-FORCE MICROSCOPY CENTRAL-NERVOUS-SYSTEM IN-VIVO MICROELECTRODE ARRAYS ELECTRICAL-PROPERTIES CORTEX NANOELECTRODES RELIABILITY FABRICATION carbon nanotubes CNT-modified electrodes tungsten microelectrodes acute neural recording sensitivity