Thambi, Thavasyappan Deepagan, V. G. Yoon, Hong Yeol Han, Hwa Seung Kim, Seol-Hee Son, Soyoung Jo, Dong-Gyu Ahn, Cheol-Hee Suh, Yung Doug Kim, Kwangmeyung Kwon, Ick Chan Lee, Doo Sung Park, Jae Hyung 2024-01-20T10:32:07Z 2024-01-20T10:32:07Z 2021-09-05 2014-02 0142-9612 https://pubs.kist.re.kr/handle/201004/127142 Hypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate. remarkably increased under the hypoxic condition. From in vitro cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions. In vivo biodistribution study demonstrated that HR-NPs were selectively accumulated at the hypoxic tumor tissues. As consequence, drug-loaded HR-NPs exhibited high anti-tumor activity in vivo. Overall, the HR-NPs might have a potential as nanocarriers for drug delivery to treat hypoxia-associated diseases. (C) 2013 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD GLYCOL CHITOSAN NANOPARTICLES CANCER-THERAPY POLY(ETHYLENE GLYCOL) FLUORESCENT MARKERS BLOCK-COPOLYMERS CELLS DOXORUBICIN CAMPTOTHECIN MECHANISMS CONJUGATE Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery Article 10.1016/j.biomaterials.2013.11.022 1 BIOMATERIALS, v.35, no.5, pp.1735 - 1743 BIOMATERIALS 35 5 1735 1743 scie scopus 000330156100038 2-s2.0-84890175659 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article GLYCOL CHITOSAN NANOPARTICLES CANCER-THERAPY POLY(ETHYLENE GLYCOL) FLUORESCENT MARKERS BLOCK-COPOLYMERS CELLS DOXORUBICIN CAMPTOTHECIN MECHANISMS CONJUGATE Hypoxia Nanoparticles 2-Nitroimidazole Bioreduction Drug delivery