Lee, Hyung-Jae Heo, Yun Park, Kyung-Tai Kim, Eun-Hye Ito, Yoshihiro Song, Kwang-Sup Han, Dong-Keun Son, Tae-Il 2024-01-20T10:32:22Z 2024-01-20T10:32:22Z 2021-09-05 2014-02 1598-5032 https://pubs.kist.re.kr/handle/201004/127155 Titanium and its alloys have been used for a wide range of dental implant materials because of their biocompatible properties. Due to the osseointegration between the bone and implant surface that is required after implantation surgery, surface modification of titanium has been investigated. Even though bone morphogenetic protein-2 (BMP-2) and other growth factors have been applied to increase the efficiency of osseointegration, their short half-life has been a disadvantage. In this study, BMP-2 was photo-immobilized on a titanium surface using azidophenyl hyaluronic acid (Az-HA) as a matrix, and C2C12 cell lines were cultured on the modified surface. The photoreactive azidophenyl hyaluronic acid was prepared and characterized in a previous report. To demonstrate the osteoinductive effect of the photo-immobilized BMPs, alkaline phosphatase (ALP) activity assay, calcium detection assay, and alizarin red staining were conducted. English POLYMER SOC KOREA EPIDERMAL-GROWTH-FACTOR COLLAGEN TYPE-I OSTEOBLAST DIFFERENTIATION ASCORBIC-ACID ADHESION ALLOY HYDROXYAPATITE PROLIFERATION DEFECTS POLYMER The immobilization of bone morphogenetic protein-2 via photo curable azidophenyl hyaluronic acid on a titanium surface and providing effect for cell differentiation Article 10.1007/s13233-014-2032-y 1 MACROMOLECULAR RESEARCH, v.22, no.2, pp.173 - 178 MACROMOLECULAR RESEARCH 22 2 173 178 scie scopus kci ART001849275 000330649000010 2-s2.0-84896718008 Polymer Science Polymer Science Article EPIDERMAL-GROWTH-FACTOR COLLAGEN TYPE-I OSTEOBLAST DIFFERENTIATION ASCORBIC-ACID ADHESION ALLOY HYDROXYAPATITE PROLIFERATION DEFECTS POLYMER titanium surface modification osteoinductive effect bone morphogenetic protein-2 (BMP-2) azidophenyl hyaluronic acid photo immobilization alkaline phosphatase (ALP) assay alizarin red S staining