Hong, Sungmin Jung, Youngmee Yen, Ringo Chan, Hon Fai Leong, Kam W. Truskey, George A. Zhao, Xuanhe 2024-01-20T10:32:35Z 2024-01-20T10:32:35Z 2021-09-05 2014-02 1473-0197 https://pubs.kist.re.kr/handle/201004/127167 We developed a microfluidic flow-control system capable of dynamically generating various flow patterns on demand. The flow-control system is based on novel magnetoactive sponges embedded in microfluidic flow channels. Applying a non-uniform magnetic field compresses the magnetoactive sponge, significantly reducing porosity and hydraulic conductivity. Tuning the applied magnetic field can dynamically vary the flow rate in the microfluidic channel. Pulsatile and physiological flow patterns with frequency between 1 and 3 Hz, flow rates between 0.5 and 10 mu L min(-1) and duration over 3 weeks have been achieved. Smooth muscle cells in engineered blood vessels perfused for 7 days aligned perpendicular to the flow direction under pulsatile but not steady flow, similar to the in vivo orientation. Owing to its various advantages over traditional flow-control methods, the new system potentially has important applications in microfluidic-based microphysiological systems to simulate the physiological nature of blood flow. English Royal Society of Chemistry SMOOTH-MUSCLE-CELLS FLUID SHEAR-STRESS POLYDIMETHYLSILOXANE PDMS SPONGE PULSATILE FLOW CULTURE MODEL CHIP GENERATOR PRESSURE ARTERIES SYNTHASE Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems Article 10.1039/c3lc51076j 1 Lab on a Chip, v.14, no.3, pp.514 - 521 Lab on a Chip 14 3 514 521 scie scopus 000328911400008 2-s2.0-84891409244 Biochemical Research Methods Chemistry, Multidisciplinary Chemistry, Analytical Nanoscience & Nanotechnology Instruments & Instrumentation Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Instruments & Instrumentation Article SMOOTH-MUSCLE-CELLS FLUID SHEAR-STRESS POLYDIMETHYLSILOXANE PDMS SPONGE PULSATILE FLOW CULTURE MODEL CHIP GENERATOR PRESSURE ARTERIES SYNTHASE