Park, Ju-Hwan Cho, Hyun-Jong Yoon, Hong Yeol Yoon, In-Soo Ko, Seung-Hak Shim, Jae-Seong Cho, Jee-Hyun Park, Jae Hyung Kim, Kwangmeyung Kwon, Ick Chan Kim, Dae-Duk 2024-01-20T10:33:22Z 2024-01-20T10:33:22Z 2021-09-05 2014-01-28 0168-3659 https://pubs.kist.re.kr/handle/201004/127205 Nanohybrid liposomes coated with amphiphilic hyaluronic acid-ceramide (HACE) was fabricated for targeted delivery of anticancer drug and in vivo cancer imaging. Nanohybrid liposomes including doxorubicin (DOX) and Magnevist, a contrast agent for magnetic resonance (MR) imaging, with 120-130 nm mean diameter and a narrow size distribution were developed. DOX release from the developed formulation was improved at acidic pH (pH 5.5 and 6.8) versus physiological pH (pH 7.4). Cytotoxicity induced by the blank plain liposome was reduced by coating the outer surface of the nanohybrid liposome with HACE. Cellular uptake of DOX from the nanohybrid liposome was enhanced by HA and CD44 receptor interaction, versus the plain liposome. In vivo contrast-enhancing effects revealed that the nanohybrid liposome can be used as a tumor targeting MR imaging probe for cancer diagnosis. In a pharmacokinetic study in rats, in vivo clearance of DOX was decreased in the order DOX solution, plain liposome (F2), and nanohybrid liposome (F3), indicating prolonged circulation of the drug in the blood stream and improved therapeutic efficacy of the nanohybrid liposome (F3). Based on these findings, the nanohybrid liposomal system may be a useful candidate for real-time cancer diagnosis and therapy. (C) 2013 Elsevier B. V. All rights reserved. English ELSEVIER SCIENCE BV SELF-ASSEMBLED NANOPARTICLES MRI CONTRAST AGENTS SURFACE-MODIFICATION IN-VITRO TARGETED DELIVERY DOXORUBICIN THERAPY DIAGNOSIS PROLONGATION FLUORESCENT Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery Article 10.1016/j.jconrel.2013.11.016 1 JOURNAL OF CONTROLLED RELEASE, v.174, pp.98 - 108 JOURNAL OF CONTROLLED RELEASE 174 98 108 scie scopus 000329964500012 2-s2.0-84888996200 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article SELF-ASSEMBLED NANOPARTICLES MRI CONTRAST AGENTS SURFACE-MODIFICATION IN-VITRO TARGETED DELIVERY DOXORUBICIN THERAPY DIAGNOSIS PROLONGATION FLUORESCENT Doxorubicin Hyaluronic acid-ceramide Hybrid nanostructure Lipid Magnetic resonance imaging