Jang, Hyeon-Lok El-Gamal, Mohammed I. Choi, Hye-Eun Choi, Ho-Yeong Lee, Kyung-Tae Oh, Chang-Hyun 2024-01-20T10:33:39Z 2024-01-20T10:33:39Z 2022-01-10 2014-01-15 0960-894X https://pubs.kist.re.kr/handle/201004/127219 The regulations of NO and PGE(2) productions are research topics of interest in the field of antiinflammatory drug development. In the present study, a series of tricyclic fused coumarin sulfonate derivatives was synthesized and evaluated for their abilities to inhibit NO and PGE(2) productions in LPS-induced RAW 264.7 macrophages. Among all the target compounds, compound 1g possessing p-(trifluoromethyl) phenyl and fused cycloheptane moieties showed the highest inhibitory effects on NO and PGE2 productions. Compound 1g not only inhibited COX-2 activity but also reduced expressions of COX-2 and iNOS. Furthermore, ADME profiling showed that compounds 1g, 1j, 1m, and 1n are estimated to be orally bioavailable. (C) 2013 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. INFLAMMATION Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE(2) productions in RAW 264.7 macrophages Article 10.1016/j.bmcl.2013.12.018 1 Bioorganic & Medicinal Chemistry Letters, v.24, no.2, pp.571 - 575 Bioorganic & Medicinal Chemistry Letters 24 2 571 575 scie scopus 000329430600032 2-s2.0-84891890612 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article INFLAMMATION Antiinflammatory Coumarin Nitric oxide PGE(2) Sulfonate Tricyclic fused coumarin