Kim, Ji Hoon Han, Im-Ho Yamabe, Noriko Kim, Young-Joo Lee, Woojung Eom, Dae-Woon Choi, Pilju Cheon, Gab Jin Jang, Hyuk-Jai Kim, Su-Nam Ham, Jungyeob Kang, Ki Sung 2024-01-20T10:33:41Z 2024-01-20T10:33:41Z 2021-09-05 2014-01-15 0308-8146 https://pubs.kist.re.kr/handle/201004/127220 The structural change of ginsenoside and the generation of Maillard reaction products (MRPs) are important to the increase in the biological activities of Panax ginseng. This study was carried out to identify the renoprotective active component of P. ginseng using the Maillard reaction model experiment with ginsenoside Re and leucine. Ginsenoside Re was gradually converted into less-polar ginsenosides Rg(2), Rg(6) and F-4 by heat-processing, followed by separation of the glucosyl moiety at carbon-20. The free radical-scavenging activity of the ginsenoside Re-leucine mixture was increased by heat-processing. The improved free radical-scavenging activity by heat-processing was mediated by the generation of MRPs from the reaction of glucose and leucine. The cisplatin-induced LLC-PK1 renal cell damage was also significantly reduced by treatment with MRPs. Moreover, the heat-processed glucose-leucine mixture (major MRPs from the ginsenoside Re-leucine mixture) showed protective effects against cisplatin-induced oxidative renal damage in rats through the inhibition of caspase-3 activation. (C) 2013 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD CISPLATIN-INDUCED NEPHROTOXICITY SCAVENGING ACTIVITY CHANGES ANTIOXIDATIVE ACTIVITIES OXIDATIVE STRESS EXTRACT DAMAGE ACID Renoprotective effects of Maillard reaction products generated during heat treatment of ginsenoside Re with leucine Article 10.1016/j.foodchem.2013.07.075 1 FOOD CHEMISTRY, v.143, pp.114 - 121 FOOD CHEMISTRY 143 114 121 scie scopus 000326207700017 2-s2.0-84881519798 Chemistry, Applied Food Science & Technology Nutrition & Dietetics Chemistry Food Science & Technology Nutrition & Dietetics Article CISPLATIN-INDUCED NEPHROTOXICITY SCAVENGING ACTIVITY CHANGES ANTIOXIDATIVE ACTIVITIES OXIDATIVE STRESS EXTRACT DAMAGE ACID Ginsenoside Maillard reaction Heat-processing Renoprotective effect