Park, Hyun Bong Lee, Jae Kyun Lee, Kang Ro Kwon, Hak Cheol 2024-01-20T10:34:03Z 2024-01-20T10:34:03Z 2021-09-05 2014-01-01 0040-4039 https://pubs.kist.re.kr/handle/201004/127238 Two new angucyclic quinones, angumycinones A (1) and B (2) and six known angucyclinone analogues (3-8) were isolated from a liquid culture extract of the Streptomyces sp. KMC004 strain from acidic coal mine drainage. The structures of these compounds were established using extensive spectroscopic data analyses, including NMR, HRFABMS, UV, CD, and X-ray crystallography. Compounds 1-8 were tested for antimicrobial activity against ten pathogenic microbial or fungal strains. Angumycinone B (2) exhibited antimicrobial activity against Micrococcus luteus, Enterococcus hirae, and methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration values of 0.78, 1.56, and 12.5 mu g/mL, respectively. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD MARINE STREPTOMYCES HATOMARUBIGIN-A ANTIBIOTICS METABOLITES GLIONITRIN RUBIGINONE DISCOVERY YM-181741 Angumycinones A and B, two new angucyclic quinones from Streptomyces sp KMC004 isolated from acidic mine drainage Article 10.1016/j.tetlet.2013.10.112 1 TETRAHEDRON LETTERS, v.55, no.1, pp.63 - 66 TETRAHEDRON LETTERS 55 1 63 66 scie scopus 000329960500010 2-s2.0-84890181985 Chemistry, Organic Chemistry Article MARINE STREPTOMYCES HATOMARUBIGIN-A ANTIBIOTICS METABOLITES GLIONITRIN RUBIGINONE DISCOVERY YM-181741 Streptomyces Angucyclinone Angumycinone Acidic mine drainage