Jang, Gun Hyuk Hwang, Mintai P. Kim, Su Yeon Jang, Ho Seong Lee, Kwan Hyi 2024-01-20T10:34:37Z 2024-01-20T10:34:37Z 2021-09-05 2014-01 0142-9612 https://pubs.kist.re.kr/handle/201004/127266 Lanthanide ion-doped nanophosphors are an emerging group of nanomaterials with excellent optical properties, and have been suggested as alternatives to quantum dots. In this letter, we determine the in-vitro and in-vivo toxicity of beta-NaYF4:Ce,Tb nanophosphors using Capan-1 cells and embryonic zebrafish, respectively. In particular, we are the first to report on the in-vivo toxicity of beta-phase nanophosphors and examine phenotypic developmental abnormalities (growth retardation, heart deformity, and bent tail), apoptotic cell death, and changes in heart function due to the nanophosphors. This study suggests the use of beta-NaYE4:Ce,Tb nanophosphors as alternatives for QDs in a wide variety of biomedical imaging applications. (C) 2013 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD NANOPARTICLES SIZE A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models Article 10.1016/j.biomaterials.2013.09.054 1 BIOMATERIALS, v.35, no.1, pp.440 - 449 BIOMATERIALS 35 1 440 449 scie scopus 000328006100044 2-s2.0-84887018799 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article NANOPARTICLES SIZE Zebrafish Toxicity Nanophosphor Quantum dot