Kim, Kyobum Lee, Kwan Hyi Lee, Jongmin Choi, Jonghoon 2024-01-20T10:34:49Z 2024-01-20T10:34:49Z 2021-09-05 2014-01 0253-6269 https://pubs.kist.re.kr/handle/201004/127277 The goal of this review is summarizing current technologies developed as the in vitro prognostic/diagnostic systems that can rapidly separate and detect circulating tumor cells (CTCs) from cancer patient's blood (1-10 CTCs of 1 billion red blood cells) by labeled and non-labeled method. The review is focused on three major areas of CTC research (1) Summary of previous research on capturing of CTCs, (2) New development of the in vitro prognostic diagnosis system of cancer that is capable of rapid separation of CTCs, (3) Future direction on development of new technologies for CTC profiling. Current CTC researches have helped on identifying patients who may benefit from chemotherapy before treatment, patients who may benefit from continued chemotherapy, and leading to clinical development of CTC-guided chemotherapy strategies. We analyze the feasibility of clinical application of these current CTC research for the ultimate goal of increasing the survivability of cancer patient. The biomolecular assays of viable CTCs from cancer patient may elucidate the mechanism of metastasis and tumor initiating cells and also may have high impact on the development of personalized medicine to overcome the incurable diseases. English PHARMACEUTICAL SOC KOREA BREAST-CANCER MOLECULAR CHARACTERIZATION LUNG-CANCER EP-CAM EXPRESSION EPCAM IDENTIFICATION Overview of current standpoints in profiling of circulating tumor cells Article 10.1007/s12272-013-0285-1 1 ARCHIVES OF PHARMACAL RESEARCH, v.37, no.1, pp.88 - 95 ARCHIVES OF PHARMACAL RESEARCH 37 1 88 95 scie scopus kci ART001910460 000329094700011 2-s2.0-84892949820 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Review BREAST-CANCER MOLECULAR CHARACTERIZATION LUNG-CANCER EP-CAM EXPRESSION EPCAM IDENTIFICATION Circulating tumor cell Nanotechnology Cell characterization