Han, Hyojeong Seo, Hong Seog Jung, Byung Hwa Woo, Kyoungja Yoo, Young Sook Kang, Min-Jung 2024-01-20T11:00:22Z 2024-01-20T11:00:22Z 2021-09-05 2014-01 0253-2964 https://pubs.kist.re.kr/handle/201004/127296 Substance P and neuropeptide Y were-discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI. English 대한화학회 Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients Article 10.5012/bkcs.2014.35.1.158 1 Bulletin of the Korean Chemical Society, v.35, no.1, pp.158 - 164 Bulletin of the Korean Chemical Society 35 1 158 164 N scie scopus kci ART001846048 000330682100026 2-s2.0-84892903136 Chemistry, Multidisciplinary Chemistry Article CREATINE-KINASE-MB HEART-FAILURE NATRIURETIC PEPTIDE TROPONIN ASSAYS NT-PROBNP MYOGLOBIN DISEASE MARKERS BRAIN PAIN Substance P Neuropeptide Y Biomarker Acute myocardial infarction LC-MS