전창배 김영훈 Dulamjav Batsuren Jigjidsuren Tunsag 노주원 판철호 이재권 2024-01-20T11:01:42Z 2024-01-20T11:01:42Z 2021-09-06 2013-12 0377-9556 https://pubs.kist.re.kr/handle/201004/127363 In this study we demonstrated whether the extract of Polygonum aviculare L. (PAE) can be applied to theimmune-stimulating responses in macrophages (Raw 264.7 cells). Cell viability was determined by WST-8 assay, and all fourdoses of PAE (5, 10, 20, and 40 μg/ml) had no significant cytotoxicity during the entire experimental period. PAE increasedthe production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO), and mRNA expressions and protein levelsof pro-inflammatory cytokines(tumor necrotic factor (TNF)-α, interleukin (IL)-1β and IL-6) in the same cells. Theseimmune-stimulating activities of PAE were found to be caused by the stimulation of NFκB signal and phosphorylation ofMAP kinases (p38, ERK and JNK). Korean 대한약학회 마디풀(Polygonum aviculare L.) 추출물의 대식구 면역증강 효과 Immune-stimulating Effects of Polygonum aviculare L. Extract on Macrophages Article 2 약 학 회 지, v.57, no.6, pp.394 - 399 약 학 회 지 57 6 394 399 kci ART001899815 Polygonum aviculare L. macophage cytokine inflammation