Lee, Yun Suk Kim, Hye Yun Youn, Hea Mee Seo, Jae Hong Kim, YoungSoo Shin, Kye Jung 2024-01-20T11:03:29Z 2024-01-20T11:03:29Z 2021-09-05 2013-11-01 0960-894X https://pubs.kist.re.kr/handle/201004/127454 To obtain modulators for reducing mitochondrial damage by the inhibition of A beta oligomer formation, 2-phenylbenzofuran derivatives were designed and prepared. Their inhibitory activity against A beta fibril formation was screened using ThT fluorescence assay, and the effect of derivatives on mitochondrial function was evaluated using JC-1 and MTT assay. 2-Phenylbenzofuran derivatives with dimethylamino group at p-position had an excellent inhibitory activity against A beta fibril formation. Particularly, compound 19m alleviated mitochondrial damage remarkably and possessed protective effects against A beta-induced cytotoxicity. (C) 2013 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. LONG-TERM POTENTIATION FERULIC ACID A-BETA ALZHEIMERS-DISEASE OXIDATIVE STRESS FIBRIL FORMATION IN-VIVO PEPTIDE DYSFUNCTION NEURONS 2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of beta-amyloid aggregation Article 10.1016/j.bmcl.2013.08.087 1 Bioorganic & Medicinal Chemistry Letters, v.23, no.21, pp.5882 - 5886 Bioorganic & Medicinal Chemistry Letters 23 21 5882 5886 scie scopus 000325483000025 2-s2.0-84885190183 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article LONG-TERM POTENTIATION FERULIC ACID A-BETA ALZHEIMERS-DISEASE OXIDATIVE STRESS FIBRIL FORMATION IN-VIVO PEPTIDE DYSFUNCTION NEURONS Alzheimer&apos s disease 2-Phenylbenzofuran A beta aggregation inhibitor Mitochondria