Kim, Jae Yeon Lee, Hwanbum Oh, Keun Sang Kweon, Seho Jeon, Ok-cheol Byun, Youngro Kim, Kwangmeyung Kwon, Ick Chan Kim, Sang Yoon Yuk, Soon Hong 2024-01-20T11:04:13Z 2024-01-20T11:04:13Z 2021-09-05 2013-11 0142-9612 https://pubs.kist.re.kr/handle/201004/127491 A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures. (C) 2013 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD DRUG-DELIVERY CORE/SHELL NANOPARTICLES LIPOSOME FUSION VESICLE FUSION EXENDIN-4 CAPSULES BILAYER RECEPTOR CORE Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus Article 10.1016/j.biomaterials.2013.07.040 1 BIOMATERIALS, v.34, no.33, pp.8444 - 8449 BIOMATERIALS 34 33 8444 8449 scie scopus 000324720700044 2-s2.0-84881663280 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article DRUG-DELIVERY CORE/SHELL NANOPARTICLES LIPOSOME FUSION VESICLE FUSION EXENDIN-4 CAPSULES BILAYER RECEPTOR CORE Core/shell nanoparticles Layer-by-layer approach Pluronics Lipid bilayers Sustained delivery of exenatide