전영식 정유정 염종경 김용기 김수남 2024-01-20T11:30:49Z 2024-01-20T11:30:49Z 2021-09-06 2013-10 1226-3591 https://pubs.kist.re.kr/handle/201004/127569 In this study, we investigated the effect of 88 marine algae extracts on melanin synthesis to develop newwhitening agents. Among varieties of marine algae tested, the ethyl acetate extracts from Endarachne binghamiae (EB),Scytosiphon lomentaria, Sargassum yezoense, Ecklonia cava and Sargassum fusiforme inhibited melanin synthesis inmelan-a cells. EB treatment showed the strongest inhibitory activity in melanin synthesis, compared with that of otherextracts. EB-mediated inhibition of melanin synthesis appeared to be associated with inhibition of α-glucosidase-dependentglycosylation of tyrosinase in melan-a cells. In addition, EB treatment did not affect mushroom tyrosinase or cell-extractedtyrosinase activity in vitro. Taken together, our findings suggest that anti-browning effect of EB on skin is mediated throughregulation of α-glucosidase activity and subsequent inhibition of tyrosinase activity and melanin synthesis, and furtherdevelopment of EB as a potential agent for skin whitening. Korean 한국자원식물학회 미역쇠(Endarachne binghamiae)추출물의 멜라닌 생성 억제 효과 Inhibitory Effect of Endarachne binghamiae Extract on Melanin Synthesis Article 10.7732/kjpr.2013.26.5.526 2 한국자원식물학회지, v.26, no.5, pp.526 - 532 한국자원식물학회지 26 5 526 532 kci ART001816784 Endarachne binghamiae Melanin Tyrosinase α-glucosidase Glycosylation