Saijilafu Hur, Eun-Mi Liu, Chang-Mei Jiao, Zhongxian Xu, Wen-Lin Zhou, Feng-Quan 2024-01-20T11:31:08Z 2024-01-20T11:31:08Z 2021-09-05 2013-10 2041-1723 https://pubs.kist.re.kr/handle/201004/127587 In contrast to neurons in the central nervous system, mature neurons in the mammalian peripheral nervous system (PNS) can regenerate axons after injury, in part, by enhancing intrinsic growth competence. However, the signalling pathways that enhance the growth potential and induce spontaneous axon regeneration remain poorly understood. Here we reveal that phosphatidylinositol 3-kinase (PI3K) signalling is activated in response to peripheral axotomy and that PI3K pathway is required for sensory axon regeneration. Moreover, we show that glycogen synthase kinase 3 (GSK3), rather than mammalian target of rapamycin, mediates PI3K-dependent augmentation of the growth potential in the PNS. Furthermore, we show that PI3K-GSK3 signal is conveyed by the induction of a transcription factor Smad1 and that acute depletion of Smad1 in adult mice prevents axon regeneration in vivo. Together, these results suggest PI3K-GSK3-Smad1 signalling as a central module for promoting sensory axon regeneration in the mammalian nervous system. English NATURE PUBLISHING GROUP DORSAL-ROOT GANGLION C-JUN CONDITIONING LESION GROWTH CONE GENETIC DISSECTION SCHWANN-CELLS SPINAL-CORD ACTIVATION NERVE AXOTOMY PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1 Article 10.1038/ncomms3690 1 NATURE COMMUNICATIONS, v.4 NATURE COMMUNICATIONS 4 scie scopus 000326473900004 2-s2.0-84892437005 Multidisciplinary Sciences Science & Technology - Other Topics Article DORSAL-ROOT GANGLION C-JUN CONDITIONING LESION GROWTH CONE GENETIC DISSECTION SCHWANN-CELLS SPINAL-CORD ACTIVATION NERVE AXOTOMY Biological sciences Cell biology Neuroscience