Kim, Young Seub Lee, Jae Kyun Pae, Ae Nim Cho, Yong Seo Min, Sun-Joon 2024-01-20T11:31:23Z 2024-01-20T11:31:23Z 2021-09-05 2013-10 0936-5214 https://pubs.kist.re.kr/handle/201004/127601 We have described a highly diastereoselective synthesis of 2,6-disubstituted 4-(dimethoxymethyl)tetrahydropyrans via TMSOTf-promoted Prins-pinacol reaction of methylene diol with acetals. This reaction provides an efficient procedure to synthesize functionalized tetrahydropyrans containing an acetal group at the C4 position with all-cis 2,4,6 relative configuration. English GEORG THIEME VERLAG KG Diastereoselective Synthesis of 2,6-Disubstituted 4-(Dimethoxymethyl)tetra-hydropyrans Using TMSOTf-Promoted Prins-Pinacol Cyclization Article 10.1055/s-0033-1339709 1 SYNLETT, v.24, no.17, pp.2292 - 2296 SYNLETT 24 17 2292 2296 N scie scopus 000325480800022 2-s2.0-84883693694 Chemistry, Organic Chemistry Article STEREOSELECTIVE-SYNTHESIS NATURAL-PRODUCTS STEREOCONTROLLED SYNTHESIS TETRAHYDROPYRANS ETHERS SPIROKETALS DERIVATIVES EFFICIENT UNITS cyclization Lewis acids oxonium ion diastereoselectivity 2 4 6-trisubstituted tetrahydropyrans