Lee, Jong-Wook Song, Jangwon Hwang, Mintai P. Lee, Kwan Hyi 2024-01-20T11:32:08Z 2024-01-20T11:32:08Z 2021-09-01 2013-10 1176-9114 https://pubs.kist.re.kr/handle/201004/127641 Bacteriophages are traditionally used for the development of phage display technology. Recently, their nanosized dimensions and ease with which genetic modifications can be made to their structure and function have put them in the spotlight towards their use in a variety of biosensors. In particular, the expression of any protein or peptide on the extraluminal surface of bacteriophages is possible by genetically engineering the genome. In addition, the relatively short replication time of bacteriophages offers researchers the ability to generate mass quantities of any given bacteriophage-based biosensor. Coupled with the emergence of various biomarkers in the clinic as a means to determine pathophysiological states, the development of current and novel technologies for their detection and quantification is imperative. In this review, we categorize bacteriophages by their morphology into M13-based filamentous bacteriophages and T4- or T7-based icosahedral bacteriophages, and examine how such advantages are utilized across a variety of biosensors. In essence, we take a comprehensive approach towards recent trends in bacteriophage-based biosensor applications and discuss their outlook with regards to the field of biotechnology. English DOVE MEDICAL PRESS LTD M13 BACTERIOPHAGE SALMONELLA-TYPHIMURIUM MAGNETOELASTIC BIOSENSORS DRUG-DELIVERY LANDSCAPE PHAGE T7 PHAGE NANOPARTICLES LIBRARIES BINDING CANCER Nanoscale bacteriophage biosensors beyond phage display Article 10.2147/IJN.S51894 1 INTERNATIONAL JOURNAL OF NANOMEDICINE, v.8, pp.3917 - 3925 INTERNATIONAL JOURNAL OF NANOMEDICINE 8 3917 3925 scie scopus 000325390400001 2-s2.0-84885755171 Nanoscience & Nanotechnology Pharmacology & Pharmacy Science & Technology - Other Topics Pharmacology & Pharmacy Review M13 BACTERIOPHAGE SALMONELLA-TYPHIMURIUM MAGNETOELASTIC BIOSENSORS DRUG-DELIVERY LANDSCAPE PHAGE T7 PHAGE NANOPARTICLES LIBRARIES BINDING CANCER biosensing M13 bacteriophage T4 bacteriophage bacterial detection Escherichia coli SPR sensor