Haque, Md. Mamunul Im, Hye-Yeon Seo, Ji-Eun Hasan, Mahbub Woo, Kyoungja Kwon, Oh-Seung 2024-01-20T11:33:42Z 2024-01-20T11:33:42Z 2021-09-05 2013-09 0260-437X https://pubs.kist.re.kr/handle/201004/127717 Quantum dots (QDs) are novel tools with multiple biological and medical applications because of their superior photoemission and photostability characteristics. However, leaching of toxic metals from QDs is of great concern. Therefore, for the successful application of QDs in bioscience, it is essential to understand their biological fate and toxicity. We investigated toxicological effects and tissue distribution of mercaptopropionic acid-conjugated cadmium selenide/cadmium sulfide (CdSe/CdS-MPA) QDs after repeated intraperitoneal injection into BALB/c mice. The mice were injected every 3days with various doses of QDs (0, 5, 10 and 25mgkg-1). The subsequent effects of QDs on plasma levels of various biomarkers were evaluated at different time points (at 0, 1, 4, 7, 10, 13 and 15days). Various tissue samples (spleen, liver, lung, kidneys, brain, heart and thymus) were collected for toxicity analysis, distribution testing, histopathological examination and inflammation assessment. No abnormal clinical signs or behaviors were recorded but the body weight of mice treated with 25mgkg-1 QDs was significantly decreased from day 7 compared with control mice. QDs were observed in the liver, spleen, lung and kidneys, but not in brain or heart. Significantly higher levels of lactate dehydrogenase and nicotinamide adenine dinucleotide phosphate oxidase were found in the plasma, liver and spleen. Histopathological examination did not show any tissue toxicity but the levels of interleukin-6, a pro-inflammatory marker, were increased in the plasma, liver and spleen. All of these findings provide insight into the observed toxicological effect levels and tissue-specific distribution of CdSe/CdS-MPA QDs. Copyright (c) 2012 John Wiley & Sons, Ltd. English WILEY Acute toxicity and tissue distribution of CdSe/CdS-MPA quantum dots after repeated intraperitoneal injection to mice Article 10.1002/jat.2775 1 JOURNAL OF APPLIED TOXICOLOGY, v.33, no.9, pp.940 - 950 JOURNAL OF APPLIED TOXICOLOGY 33 9 940 950 N scie scopus 000325923300011 2-s2.0-84880700115 Toxicology Toxicology Article BIOLOGICAL INTERACTIONS CARBON NANOTUBES NANOPARTICLES CADMIUM FATE PARTICLES APOPTOSIS STRESS CELLS DRUG acute toxicity tissue distribution CdSe/CdS-MPA quantum dots mice repeated intraperitoneal injection lactate dehydrogenase NADPH oxidase