Kim, Don-Kyu Gang, Gil-Tae Ryu, Dongryeol Koh, Minseob Kim, Yo-Na Kim, Su Sung Park, Jinyoung Kim, Yong-Hoon Sim, Taebo Lee, In-Kyu Choi, Cheol Soo Park, Seung Bum Lee, Chul-Ho Koo, Seung-Hoi Choi, Hueng-Sik 2024-01-20T11:34:01Z 2024-01-20T11:34:01Z 2021-09-04 2013-09 0012-1797 https://pubs.kist.re.kr/handle/201004/127734 Type 2 diabetes mellitus (T2DM) is a progressive metabolic disorder with diverse pathological manifestations and is often associated with abnormal regulation of hepatic glucose production. Many nuclear receptors known to control the hepatic gluconeogenic program are potential targets for the treatment of T2DM and its complications. Nevertheless, the therapeutic potential of the estrogen-related receptor (ERR) in T2DM remains unknown. In this study, we show that the nuclear receptor ERR is a major contributor to hyperglycemia under diabetic conditions by controlling hepatic glucose production. Hepatic ERR expression induced by fasting and diabetic conditions resulted in elevated levels of gluconeogenic gene expression and blood glucose in wild-type mice. Conversely, ablation of hepatic ERR gene expression reduced the expression of gluconeogenic genes and normalized blood glucose levels in mouse models of T2DM: db/db and diet-induced obesity (DIO) mice. In addition, a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERR gamma-specific inverse agonist, in db/db and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production. Our findings suggest that the ability of GSK5182 to control hepatic glucose production can be used as a novel therapeutic approach for the treatment of T2DM. English AMER DIABETES ASSOC PHOSPHATIDIC-ACID PHOSPHATASE ESTROGEN-RELATED RECEPTORS ALPHA GENE-EXPRESSION INSULIN-RESISTANCE TRANSCRIPTION REGULATOR LIPIN1 LIVER PGC-1 Inverse Agonist of Nuclear Receptor ERR gamma Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis Article 10.2337/db12-0946 1 DIABETES, v.62, no.9, pp.3093 - 3102 DIABETES 62 9 3093 3102 scie scopus 000323421000016 2-s2.0-84887397982 Endocrinology & Metabolism Endocrinology & Metabolism Article PHOSPHATIDIC-ACID PHOSPHATASE ESTROGEN-RELATED RECEPTORS ALPHA GENE-EXPRESSION INSULIN-RESISTANCE TRANSCRIPTION REGULATOR LIPIN1 LIVER PGC-1 diabetes ERR