Kim, Hyun-Jin El-Gamal, Mohammed I. Lee, Yong Sup Oh, Chang-Hyun 2024-01-20T11:34:41Z 2024-01-20T11:34:41Z 2022-01-10 2013-08-20 0253-2964 https://pubs.kist.re.kr/handle/201004/127763 A new series of diarylamides and diarylureas having 2,3-dihydropyrrolo[3,2-b]quinoline scaffold was synthesized. Their in vitro antiproliferative activities were tested over NCI-60 cancer cell lines of nine different cancer types. Some target compounds showed good inhibition percentages over different cell lines. Among all the target compounds, compound if possessing 6,7-dimethoxy-2,3-clihydropyrrolo[3,2-b]quinoline nucleus, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed high selectivity against MCF7 and MDA-MB-468 breast cancer cell lines more than the other tested cell lines. Its inhibition percentages at 10 mu M concentration over those two cell lines were 84.97% and 87.13%, respectively. English KOREAN CHEMICAL SOC MELANOMA-CELL LINE ANTIPROLIFERATIVE ACTIVITY 1,3,4-TRIARYLPYRAZOLE SCAFFOLD TYROSINE KINASE CANCER-CELLS DERIVATIVES DESIGN INHIBITORS DISCOVERY GROWTH Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold Article 10.5012/bkcs.2013.34.8.2480 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.8, pp.2480 - 2486 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 34 8 2480 2486 scie scopus kci ART001793453 000323854400048 2-s2.0-84884148206 Chemistry, Multidisciplinary Chemistry Article MELANOMA-CELL LINE ANTIPROLIFERATIVE ACTIVITY 1,3,4-TRIARYLPYRAZOLE SCAFFOLD TYROSINE KINASE CANCER-CELLS DERIVATIVES DESIGN INHIBITORS DISCOVERY GROWTH 2,3-Dihydropyrrolo[3,2-b]quinoline Urea Amide Antiproliferative activity Breast cancer