Shim, Young Sun Hwang, Hyun Sook Nam, Ghilsoo Choi, Kyung Il 2024-01-20T11:34:42Z 2024-01-20T11:34:42Z 2021-09-05 2013-08-20 0253-2964 https://pubs.kist.re.kr/handle/201004/127764 Thiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inflammatory activity. Both series of compounds showed moderate activity on HO-I induction, and no inhibitory effect on NO production. Interestingly the thiourea compound 6d showed better HO-1 induction (71% SFN) than the corresponding isothiocyanate compound 6a (55% SFN). Overall, it seemed that more efficient electrophile is needed to get more effective Nrf2 activator. English KOREAN CHEMICAL SOC TRANSCRIPTION FACTOR NRF2 PARKINSONS-DISEASE ELEMENT SYSTEMS TARGET ASSAY GENE Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives Article 10.5012/bkcs.2013.34.8.2317 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.8, pp.2317 - 2320 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 34 8 2317 2320 scie scopus kci ART001793423 000323854400018 2-s2.0-84884165363 Chemistry, Multidisciplinary Chemistry Article TRANSCRIPTION FACTOR NRF2 PARKINSONS-DISEASE ELEMENT SYSTEMS TARGET ASSAY GENE Thiourea Vinyl sulfoxide Nrf2 activator Parkinson&apos s disease Oxidative stress