Kim, Hee Jin Oh, Chang-Hyun Yoo, Kyung Ho 2024-01-20T11:34:43Z 2024-01-20T11:34:43Z 2021-09-05 2013-08-20 0253-2964 https://pubs.kist.re.kr/handle/201004/127765 A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds la-c, k and 2b-d, f, g, j, 1 showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 21 possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale. English KOREAN CHEMICAL SOC DESIGN SORAFENIB DIAGNOSIS THERAPY Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line Article 10.5012/bkcs.2013.34.8.2311 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.8, pp.2311 - 2316 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 34 8 2311 2316 scie scopus kci ART001793422 000323854400017 2-s2.0-84884164357 Chemistry, Multidisciplinary Chemistry Article DESIGN SORAFENIB DIAGNOSIS THERAPY Antiproliferative activity Pyrimidinylaminobenzene Diarylamide Diarylurea Melanoma