Lee, Hyosung Park, Ki Duk Yang, Xiao-Fang Dustrude, Erik T. Wilson, Sarah M. Khanna, Rajesh Kohn, Harold 2024-01-20T12:01:44Z 2024-01-20T12:01:44Z 2021-08-31 2013-07-25 0022-2623 https://pubs.kist.re.kr/handle/201004/127859 We have reported that compounds containing a biaryl linked unit (Ar-X-Ar') modulated Na+ currents by promoting slow inactivation and fast inactivation processes and by inducing frequency (use)-dependent inhibition of Na+ currents. These electrophysiological properties have been drugs. In this study, we demonstrate that the readily accessible associated with the mode of action of several antiepileptic (biphenyl-4-yl)methylammonium chlorides (compound class B) exhibited a broad range of anticonvulsant activities in animal models, and in the maximal electroshock seizure test the activity of (3'-trifluoromethoxybiphenyl-4-yl)methylammonium chloride (8) exceeded that of phenobarbital and phenytoin upon oral administration to rats. Electrophysiological studies of 8 using mouse catecholamine A-differentiated cells and rat embryonic cortical neurons confirmed that 8 promoted slow and fast inactivation in both cell types but did not affect the frequency (use)-dependent block of Na+ currents. English AMER CHEMICAL SOC GATED SODIUM-CHANNELS SLOW INACTIVATION IDENTIFICATION (Biphenyl-4-yl)methylammonium Chlorides: Potent Anticonvulsants That Modulate Na+ Currents Article 10.1021/jm4007092 1 JOURNAL OF MEDICINAL CHEMISTRY, v.56, no.14, pp.5931 - 5939 JOURNAL OF MEDICINAL CHEMISTRY 56 14 5931 5939 scie scopus 000322503000023 2-s2.0-84880890072 Chemistry, Medicinal Pharmacology & Pharmacy Article GATED SODIUM-CHANNELS SLOW INACTIVATION IDENTIFICATION anticonvulsant epilepsy lacosamide sodium channel slow inactivation