Lim, Chang-Keun Heo, Jeongyun Shin, Seunghoon Jeong, Keunsoo Seo, Young Hun Jang, Woo-Dong Park, Chong Rae Park, Soo Young Kim, Sehoon Kwon, Ick Chan 2024-01-20T12:02:16Z 2024-01-20T12:02:16Z 2021-09-04 2013-07-01 0304-3835 https://pubs.kist.re.kr/handle/201004/127885 Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers (NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical functions is a promising approach for improving PDT. In this review, we focus on four nanomedical approaches for advanced PDT: (1) nanocarriers for targeted delivery of PS, (2) introduction of active targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4) photophysical improvements in NPS for enhanced PDT efficacy. (C) 2012 Elsevier Ireland Ltd. All rights reserved. English ELSEVIER IRELAND LTD ORGANICALLY MODIFIED SILICA SINGLET OXYGEN GENERATION 2-PHOTON PHOTOSENSITIZED PRODUCTION IN-VITRO ENERGY-TRANSFER VASCULAR-PERMEABILITY RADIATION-THERAPY MOLECULAR BEACON BLOCK-COPOLYMER DRUG-DELIVERY Nanophotosensitizers toward advanced photodynamic therapy of Cancer Article 10.1016/j.canlet.2012.09.012 1 CANCER LETTERS, v.334, no.2, pp.176 - 187 CANCER LETTERS 334 2 176 187 scie scopus 000320492700003 2-s2.0-84878240072 Oncology Oncology Review ORGANICALLY MODIFIED SILICA SINGLET OXYGEN GENERATION 2-PHOTON PHOTOSENSITIZED PRODUCTION IN-VITRO ENERGY-TRANSFER VASCULAR-PERMEABILITY RADIATION-THERAPY MOLECULAR BEACON BLOCK-COPOLYMER DRUG-DELIVERY Photodynamic therapy Photosensitizer Nanomedicine Nanotherapeutics