Cho, Jung-Kyo Hong, Ji Min Han, Taesu Yang, Han-Kwang Song, Soo-Chang 2024-01-20T12:02:35Z 2024-01-20T12:02:35Z 2021-09-05 2013-07 1061-186X https://pubs.kist.re.kr/handle/201004/127901 Although docetaxel (DTX) is an advanced taxoid, further augmentation of its properties is still required, such as improvement in its low aqueous solubility. Herein, we report the development of biodegradable/injectable poly(organophosphazene) (PPZ) hydrogels for the delivery of DTX without the use of organic solvents. An aqueous solution of PPZ containing alpha-amino-omega-methoxy-poly(ethylene glycol) (AMPEG) 750 instead of AMPEG 550 was prepared, thereby increasing the erosion capacity of the hydrogel by judicious balance of the hydrophobic/hydrophilic moieties. The safety of the hydrogel was demonstrated using a biocompatibility test. The PPZ aqueous solution (8 wt%) containing DTX exhibited a thermosensitive sol-gel-sol transition that was independent of the concentration of DTX (1-3 mg/mL). The in vitro release study indicated that the dominant release mechanism was either erosion or diffusion/erosion-controlled release depending on the DTX content of the hydrogel. The in vivo anticancer effect of the intratumorally injected PPZ system in human gastric cancer cell-xenografted mice was evaluated, which demonstrated a significantly (p<0.01) enhanced effect of the DTX-PPZ hydrogel system compared to the control (DTX solution, i.v.). In conclusion, the PPZ hydrogel may be a promising candidate for DTX delivery, affecting a decrease in the size of tumors with little toxicity prior to exeresis. English INFORMA HEALTHCARE BIOMEDICAL APPLICATIONS CONTROLLED-RELEASE DRUG-RELEASE FORMULATIONS DOXORUBICIN POLYPHOSPHAZENES THERAPEUTICS Injectable and biodegradable poly(organophosphazene) hydrogel as a delivery system of docetaxel for cancer treatment Article 10.3109/1061186X.2013.776055 1 JOURNAL OF DRUG TARGETING, v.21, no.6, pp.564 - 573 JOURNAL OF DRUG TARGETING 21 6 564 573 scie scopus 000321151300005 2-s2.0-84879772205 Pharmacology & Pharmacy Pharmacology & Pharmacy Article BIOMEDICAL APPLICATIONS CONTROLLED-RELEASE DRUG-RELEASE FORMULATIONS DOXORUBICIN POLYPHOSPHAZENES THERAPEUTICS Biodegradable polymers controlled drug delivery docetaxel gastric cancer hydrogels injectable poly(organophosphazene) sustained-release system thermosensitive