Jeong, Keunsoo Lee, Yong-Deok Park, Solji Lee, Eunjung Lim, Chang-Keun Lee, Kyung Eun Jeon, Hyesung Kim, Jungahn Kwon, Ick Chan Park, Chong Rae Kim, Sehoon 2024-01-20T12:03:17Z 2024-01-20T12:03:17Z 2021-09-01 2013-07 2050-7518 https://pubs.kist.re.kr/handle/201004/127938 Hydrogen bonding is a major intermolecular interaction for self-assembly occurring in nature. Here we report novel polymeric carbohydrates, i.e., poly(oxyethylene galactaramide)s (PEGAs), as biomimetic building blocks to construct hydrogen bond-mediated self-assembled nanoparticles that are useful for biomedical in vivo applications. PEGAs were conceptually designed as a biocompatible hybrid between polysaccharide and poly(ethylene glycol) (PEG) to attain multivalent hydrogen bonding as well as fully hydrophilic, non-ionic and antifouling characteristics. It was revealed that PEGAs are capable of homospecies hydrogen bonding in water and constructing multi-chain assembled nanoparticles whose structural integrity is highly stable with varying concentration, temperature and pH. Using near-infrared fluorescence imaging we demonstrate facile blood circulation and efficient tumor accumulation of the self-assembled PEGA nanoparticles that were intravenously injected into mice. These in vivo behaviors elucidate the combined merits of our design strategy, i.e., biocompatible chemical constitution capable of multivalent hydrogen bonding, antifouling properties, minimal cell interaction and mesoscopic colloidal self-assembly, as well as size-motivated tumor targeting. English ROYAL SOC CHEMISTRY INTERPOLYMER COMPLEX POLY(ACRYLIC ACID) CONTROLLED-RELEASE NANOPARTICLES MICELLES POLYMERS LIGHT Poly(oxyethylene sugaramide)s: unprecedented multihydroxyl building blocks for tumor-homing nanoassembly Article 10.1039/c3tb20387e 1 JOURNAL OF MATERIALS CHEMISTRY B, v.1, no.28, pp.3437 - 3442 JOURNAL OF MATERIALS CHEMISTRY B 1 28 3437 3442 scie scopus 000320951700001 2-s2.0-84879970536 Materials Science, Biomaterials Materials Science Article INTERPOLYMER COMPLEX POLY(ACRYLIC ACID) CONTROLLED-RELEASE NANOPARTICLES MICELLES POLYMERS LIGHT