Kim, Eunhee Kim, Misuk Woo, Dong-Hun Shin, Yongjae Shin, Jihye Chang, Nakho Oh, Young Taek Kim, Hong Rheey, Jingeun Nakano, Ichiro Lee, Cheolju Joo, Kyeung Min Rich, Jeremy N. Nam, Do-Hyun Lee, Jeongwu 2024-01-20T12:03:57Z 2024-01-20T12:03:57Z 2021-09-05 2013-06-10 1535-6108 https://pubs.kist.re.kr/handle/201004/127968 Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homo log 2 (EZH2), the lysine methyltransferase of Polycomb repressive complex 2, mediates transcriptional repression of prodifferentiation genes in both normal and neoplastic stem cells. An oncogenic role of EZH2 as a transcriptional silencer is well established; however, additional functions of EZH2 are incompletely understood. Here, we show that EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. The EZH2-STAT3 interaction preferentially occurs in GSCs relative to non-stem bulk tumor cells, and it requires a specific phosphorylation of EZH2. Inhibition of EZH2 reverses the silencing of Polycomb target genes and diminishes STAT3 activity, suggesting therapeutic strategies. English CELL PRESS TUMOR-INITIATING CELLS GROUP PROTEIN EZH2 NF-KAPPA-B HISTONE METHYLTRANSFERASE DEVELOPMENTAL REGULATORS MEDIATED REPRESSION GENE-EXPRESSION POLYCOMB CANCER INHIBITOR Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells Article 10.1016/j.ccr.2013.04.008 1 CANCER CELL, v.23, no.6, pp.839 - 852 CANCER CELL 23 6 839 852 scie scopus 000320350900015 2-s2.0-84879000598 Oncology Cell Biology Oncology Cell Biology Article TUMOR-INITIATING CELLS GROUP PROTEIN EZH2 NF-KAPPA-B HISTONE METHYLTRANSFERASE DEVELOPMENTAL REGULATORS MEDIATED REPRESSION GENE-EXPRESSION POLYCOMB CANCER INHIBITOR