Lee, Dong Hyun Kim, Yoon Suk Lim, Jaewon Cho, Yoonjung Jung, Byung Chul Pan, Cheol-Ho Kim, Hyun-Kyung Rhee, Ki-Jong 2024-01-20T12:04:36Z 2024-01-20T12:04:36Z 2021-09-05 2013-06 1976-9571 https://pubs.kist.re.kr/handle/201004/128000 Triglyceride (TG) is known to be associated with inflammatory diseases including atherosclerosis. At the cellular level, TG can act as an immunomodulatory stimulus for macrophages. In this study we show that TG treatment of PMA-differentiated macrophages resulted in down-regulation of MMP-12 expression in a time- and dose-dependent manner. MMP-19 expression was unaffected by TG treatment. Using a variety of chemical inhibitors for cell signaling pathways we demonstrate that TG-induced down-regulation of MMP-12 occurs in part by activation of the NF-kappa B pathway. Finally, TG treatment of PMA-differentiated macrophages decreased cell migration in a wound healing assay. Taken together our data suggests that one function of TG is to modulate macrophage migration in tissues. English SPRINGER CANCER KERATINOCYTES INFLAMMATION Triglyceride down-regulates matrix metalloprotease-12 expression in THP-1 macrophages through activation of the NF-kappa B pathway Article 10.1007/s13258-013-0105-5 1 GENES & GENOMICS, v.35, no.3, pp.405 - 409 GENES & GENOMICS 35 3 405 409 scie scopus kci ART001776353 000319614200014 2-s2.0-84878769843 Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Article CANCER KERATINOCYTES INFLAMMATION MMP-12 Atherosclerosis THP-1 macrophage Triglyceride