Kim, Young-Min Park, Mi-Ran Song, Soo-Chang 2024-01-20T12:05:02Z 2024-01-20T12:05:02Z 2021-09-04 2013-06 0142-9612 https://pubs.kist.re.kr/handle/201004/128023 An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophosphazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organophosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection. (C) 2013 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD RNA INTERFERENCE An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery Article 10.1016/j.biomaterials.2013.02.050 1 BIOMATERIALS, v.34, no.18, pp.4493 - 4500 BIOMATERIALS 34 18 4493 4500 scie scopus 000317884800009 2-s2.0-84875607485 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article RNA INTERFERENCE Cell penetration Gene delivery Nano-polyplex Polyplex hydrogel Small interference RNA (siRNA)