Kum, Chang Hun Cho, Youngjin Joung, Yoon Ki Choi, Jiyeon Park, Kwideok Seo, Seong Ho Park, Yong Seek Ahn, Dong Jun Han, Dong Keun 2024-01-20T12:05:15Z 2024-01-20T12:05:15Z 2021-09-01 2013-06 2050-7518 https://pubs.kist.re.kr/handle/201004/128034 Biodegradable polymers, such as poly(L-lactide) (PLLA), are very useful in many biomedical applications. However, their degradation by-products have been much of a concern as they are the sources of inflammatory reactions in the body. In this work, we suggest a novel composite system composed of PLLA and oligolactide-grafted magnesium hydroxide (Mg-OLA) that can overcome drawbacks caused by poor mechanical properties and inflammatory response of PLLA for biomedical applications. Mg-OLAs were synthesized by ring opening polymerization and the structure, morphology, pH change, thermal, and mechanical properties were analyzed using FTIR, SEM, pH meter, TGA, and UTM. In particular, the tensile strength and modulus of PLLA/Mg80-OLA20 (0-20 wt%) were higher than those of PLLA/magnesium hydroxide. The PLLA/Mg80-OLA20 composite was also very effective in neutralizing the acidic environment caused by the degradable by-product of the PLLA matrix. In vitro cell viability and the expression levels of COX-2 and IL-6 proteins in the PLLA composites were also evaluated. Cell viability increased to around 100% with increasing the amount of Mg80-OLA20 from 0 to 20 wt%. The expression levels of IL-6 and COX-2 were reduced dramatically when increasing the proportion of Mg80-OLA20 from 0 to 50 wt%. As a result, the incorporation of Mg-OLAs into the PLLA matrix could reinforce the mechanical properties as well as reduce the inflammatory response of the hybrid PLLA. Therefore, this hybrid composite system blending oligomer-grafted magnesium hydroxide in biodegradable polymers would be a promising strategy for avoiding current fatal problems in biomedical applications. English ROYAL SOC CHEMISTRY THERMAL-DECOMPOSITION L-LACTIDE SURFACE HYDROXYAPATITE POLYMERS DELIVERY BIOCOMPATIBILITY POLYMERIZATION DRUG Biodegradable poly(L-lactide) composites by oligolactide-grafted magnesium hydroxide for mechanical reinforcement and reduced inflammation Article 10.1039/c3tb00490b 1 JOURNAL OF MATERIALS CHEMISTRY B, v.1, no.21, pp.2764 - 2772 JOURNAL OF MATERIALS CHEMISTRY B 1 21 2764 2772 scie scopus 000318568600011 2-s2.0-84877667539 Materials Science, Biomaterials Materials Science Article THERMAL-DECOMPOSITION L-LACTIDE SURFACE HYDROXYAPATITE POLYMERS DELIVERY BIOCOMPATIBILITY POLYMERIZATION DRUG Biodegradablepoly