Ma, Sisi Pawlak, Anthony P. Cho, Jeiwon Root, David H. Barker, David J. West, Mark O. 2024-01-20T12:31:04Z 2024-01-20T12:31:04Z 2021-08-31 2013-05-01 0166-4328 https://pubs.kist.re.kr/handle/201004/128079 Amphetamine elicits motoric changes by increasing the activity of central neurotransmitters such as dopamine and serotonin, but how these neurochemical signals are transduced into motor commands is unclear. The dorsolateral striatum (DLS), a component of the cortico-subcortical reentrant motor loop, contains abundant neurotransmitter transporters that amphetamine could affect. It has been hypothesized that DLS medium spiny neurons contribute to amphetamine's motor effects. To study striatal activity contributing to amphetamine-induced movements, activity of DLS neurons related to vertical head movement was recorded while tracking head movements before and after acute amphetamine injection. Relative to saline, all amphetamine doses induced head movements above pre-injection levels, revealing an inverted U-shaped dose-response function. Lower doses (1 mg/kg and 2 mg/kg, intraperitoneal) induced a greater number of long (distance and duration) movements than the high dose (4 mg/kg), which induced stereotypy. Firing rates (FR) of individual head movement neurons were compared before and after injection during similar head movements, defined by direction, distance, duration, and apex. Changes in FR induced by amphetamine were co-determined by dose and pre-injection FR of the neuron. Specifically, all doses increased the FRs of slower firing neurons but decreased the FRs of faster firing neurons. The magnitudes of elevation or reduction were greater at lower doses, but less pronounced at the high dose, forming an inverted U function. Modulation of DLS firing may interfere with sensorimotor processing. Furthermore, pervasive elevation of slow firing neurons' FRs may feed-forward and increase excitability in thalamocortical premotor areas, contributing to the increased movement initiation rate. (C) 2013 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV FREELY MOVING RATS NUCLEUS-ACCUMBENS NEOSTRIATAL NEURONS LATERAL STRIATUM SINGLE NEURONS SEROTONIN TRANSPORTER DOPAMINE TRANSPORTER UNRESTRAINED RATS CAUDATE-NUCLEUS PRIMATE PUTAMEN Amphetamine's dose-dependent effects on dorsolateral striatum sensorimotor neuron firing Article 10.1016/j.bbr.2013.01.044 1 BEHAVIOURAL BRAIN RESEARCH, v.244, pp.152 - 161 BEHAVIOURAL BRAIN RESEARCH 244 152 161 scie scopus 000316833100019 2-s2.0-84874542768 Behavioral Sciences Neurosciences Behavioral Sciences Neurosciences & Neurology Article FREELY MOVING RATS NUCLEUS-ACCUMBENS NEOSTRIATAL NEURONS LATERAL STRIATUM SINGLE NEURONS SEROTONIN TRANSPORTER DOPAMINE TRANSPORTER UNRESTRAINED RATS CAUDATE-NUCLEUS PRIMATE PUTAMEN DLS, dorsolateral striatum FR, firing rate DAT, dopamine transporter SERT, serotonin transporter NET, norepinephrine transporter M1, primary motor cortex S1, primary somatosensory cortex SBP neuron, single body part neuron PETH, pen-event time histogram HLM, hierarchical linear model GLIMMIX, generalized linear mixed models Dorsolateral striatum Amphetamine Motoric behavior