Kim, Min Cheol Kwon, Oh-Wook Park, Jin-Soo Kim, Sun Yeou Kwon, Hak Cheol 2024-01-20T12:31:33Z 2024-01-20T12:31:33Z 2021-09-05 2013-05 0009-2363 https://pubs.kist.re.kr/handle/201004/128104 Three new 3,6-disubstituted alpha-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E-2 (PGE(2)) and interleukin-1 beta (IL-1 beta). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 mu M in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. English PHARMACEUTICAL SOC JAPAN NITRIC-OXIDE SYNTHASE SP-NOV. NEUROPROTECTIVE ROLE NATURAL-PRODUCTS IMMUNE-SYSTEM A-D MICROGLIA NEUROTOXICITY DERIVATIVES INHIBITORS Nocapyrones H-J, 3,6-Disubstituted alpha-Pyrones from the Marine Actinomycete Nocardiopsis sp KMF-001 Article 10.1248/cpb.c12-00956 1 CHEMICAL & PHARMACEUTICAL BULLETIN, v.61, no.5, pp.511 - 515 CHEMICAL & PHARMACEUTICAL BULLETIN 61 5 511 515 scie scopus 000318331300003 2-s2.0-84878772964 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article NITRIC-OXIDE SYNTHASE SP-NOV. NEUROPROTECTIVE ROLE NATURAL-PRODUCTS IMMUNE-SYSTEM A-D MICROGLIA NEUROTOXICITY DERIVATIVES INHIBITORS nocapyrone H nocapyrone I nocapyrone J Nocardiopsis sp. neuro-protective effect