Mun, Cho Hay Kim, Sang-Hoon Jung, Youngmee Kim, Sang-Heon Kim, Ae-kyeong Kim, Dong-Ik Kim, Soo Hyun 2024-01-20T12:31:52Z 2024-01-20T12:31:52Z 2021-09-04 2013-05 0883-9115 https://pubs.kist.re.kr/handle/201004/128121 Synthetic vessel grafts have been used as vascular substitutes for cardiovascular bypass procedures. In this study, we developed a novel tubular double-layered poly(l-lactide-co-E-caprolactone) scaffold that did not require pretreatment with cell seeding by promoting autologous tissue regeneration by inducing the proliferation and differentiation of endothelial and smooth muscle progenitor cells after implantation. The patency and mechanical properties were maintained for one year after implantation, although 95% of the poly(l-lactide-co-E-caprolactone) scaffolds had degraded. After this period, there was a lining of endothelial cells, an accumulation of collagen and elastin, and the development of neovascularization inside the poly(l-lactide-co-E-caprolactone). English SAGE PUBLICATIONS LTD IN-VIVO ENDOTHELIAL-CELLS GRAFT BIOMATERIALS REGENERATION FABRICATION COPOLYMER EVENTS GROWTH Elastic, double-layered poly (l-lactide-co-E-caprolactone) scaffold for long-term vascular reconstruction Article 10.1177/0883911513477750 1 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, v.28, no.3, pp.233 - 246 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 28 3 233 246 scie scopus 000323667500004 2-s2.0-84878237138 Biotechnology & Applied Microbiology Materials Science, Biomaterials Polymer Science Biotechnology & Applied Microbiology Materials Science Polymer Science Article IN-VIVO ENDOTHELIAL-CELLS GRAFT BIOMATERIALS REGENERATION FABRICATION COPOLYMER EVENTS GROWTH Poly(l-lactide-co-caprolactone) vascular graft without cells endothelial cell lining neovascularization elastomer cardiovascular bypass