Kim, Ji Won Roh, Jong-Lyel Kim, Jae Seung Lee, Jeong Hyun Cho, Kyung-Ja Choi, Seung-Ho Nam, Soon Yuhl Kim, Sang Yoon 2024-01-20T12:31:54Z 2024-01-20T12:31:54Z 2021-09-04 2013-05 1368-8375 https://pubs.kist.re.kr/handle/201004/128123 Objectives: Central compartment lymph node metastasis (CLNM) in patients with laryngeal, hypopharyngeal, or cervical esophageal squamous cell carcinoma is associated with unfavorable clinical outcomes, but cannot be reliably detected using computed tomography (CT)/magnetic resonance imaging (MRI). Therefore, we assessed the clinical utility of using F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT to identify CLNM in these patients. Patients and methods: A total of 62 patients were preoperatively evaluated using F-18-FDG PET/CT and CT/MRI. Histopathologic analysis of the dissected neck tissues was used as the gold standard for assessing these imaging techniques. The diagnostic value of F-18-FDG PET/CT for detecting CLNM was calculated and compared with CT/MRI. Univariate and multivariate analyses were utilized to determine the factors predictive of CLNM. Results: Of the 62 patients in the study cohort, 12 (19%) had CLNM. Compared with histology, both F-18-FDG PET/CT and CT/MRI demonstrated low sensitivity for detecting CLNM (58% vs 42%, respectively, P = 0.625). The specificities of F-18-FDG PET/CT and CT/MRI for the detection of CLNM were 88% and 90%, respectively (P = 1.000). Univariate and multivariate analyses showed that clinical metastasis to any cervical lymph node was significantly associated with CLNM (P = 0.018). Conclusions: Neither F-18-FDG PET/CT nor CT/MRI is a sensitive diagnostic imaging modality for detecting CLNM. Routine elective central compartment dissection or radiotherapy should be advocated for the treatment of these patients. (C) 2012 Elsevier Ltd. All rights reserved. English ELSEVIER SCIENCE BV POSITRON-EMISSION-TOMOGRAPHY LYMPH-NODE METASTASIS CERVICAL ESOPHAGUS HEAD CANCER CT CLASSIFICATION Evaluation of F-18-FDG PET/CT and CT/MRI with histopathologic correlation in patients undergoing central compartment neck dissection for squamous cell carcinoma of the larynx, hypopharynx, and esophagus Article 10.1016/j.oraloncology.2012.12.007 1 ORAL ONCOLOGY, v.49, no.5, pp.449 - 453 ORAL ONCOLOGY 49 5 449 453 scie scopus 000317265300011 2-s2.0-84875717583 Oncology Dentistry, Oral Surgery & Medicine Oncology Dentistry, Oral Surgery & Medicine Article POSITRON-EMISSION-TOMOGRAPHY LYMPH-NODE METASTASIS CERVICAL ESOPHAGUS HEAD CANCER CT CLASSIFICATION Central compartment Lymph node metastasis Squamous cell carcinoma Detection F-18-FDG PET/CT CT/MRI