El-Gamal, Mohammed I. Anbar, Hanan S. Yoo, Kyung Ho Oh, Chang-Hyun 2024-01-20T12:33:03Z 2024-01-20T12:33:03Z 2022-01-10 2013-04 0198-6325 https://pubs.kist.re.kr/handle/201004/128178 FMS, first discovered as the oncogene responsible for Feline McDonough Sarcoma, is a type III receptor tyrosine kinase that binds to the macrophage or monocyte colony-stimulating factor (M-CSF or CSF-1). Signal transduction through that binding results in survival, proliferation, and differentiation of monocyte/macrophage lineage. Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states such as the growth of metastasis of certain types of cancer, in promoting osteoclast proliferation in bone osteolysis, and many inflammatory disorders. Inhibition of CSF-1 and/or FMS may help treat these pathological conditions. This article reviews FMS gene, FMS kinase, CSF-1, IL-34, and their roles in bone osteolysis, cancer biology, and inflammation. Monoclonal antibodies, FMS crystal structure, and small molecule FMS kinase inhibitors of different chemical scaffolds are also reviewed. English WILEY COLONY-STIMULATING FACTOR FACTOR-I RECEPTOR TUMOR-ASSOCIATED MACROPHAGES COLLAGEN-INDUCED ARTHRITIS BONE METASTASIS MODEL RENAL-CELL CARCINOMA SMOOTH-MUSCLE-CELLS PROTOONCOGENE C-FMS BREAST-CANCER CELLS M-CSF RECEPTOR FMS Kinase Inhibitors: Current Status and Future Prospects Article 10.1002/med.21258 1 MEDICINAL RESEARCH REVIEWS, v.33, no.3, pp.599 - 636 MEDICINAL RESEARCH REVIEWS 33 3 599 636 scie scopus 000317616000004 2-s2.0-84876082442 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Review COLONY-STIMULATING FACTOR FACTOR-I RECEPTOR TUMOR-ASSOCIATED MACROPHAGES COLLAGEN-INDUCED ARTHRITIS BONE METASTASIS MODEL RENAL-CELL CARCINOMA SMOOTH-MUSCLE-CELLS PROTOONCOGENE C-FMS BREAST-CANCER CELLS M-CSF RECEPTOR FMS CSF-1 CSF-1R IL-34 monoclonal antibodies FMS kinase inhibitors