Shin, Hyo-Nim Seo, Seon Hee Choo, Hyunah Kuem, Gyochang Choi, Kyung Il Nam, Ghilsoo 2024-01-20T12:34:43Z 2024-01-20T12:34:43Z 2021-09-01 2013-03-01 0960-894X https://pubs.kist.re.kr/handle/201004/128259 A novel series of 5(R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl]oxazolidinones having various piperidine group were synthesized and evaluated antibacterial activity against clinically isolated resistant strains of Gram-positive and Gram-negative bacteria. The compound 12a having exo-cyanoethylidene group in the 4-position of piperidine ring was found to be two to threefold more potent than the linezolid against penicillin-resistant Staphylococcus pneumonia and Staphylococcus agalactiae, and also exhibited reduced MAO-B inhibitory activity. (C) 2013 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. IN-VITRO ACTIVITY IDENTIFICATION Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl]oxazolidinones Article 10.1016/j.bmcl.2013.01.033 1 Bioorganic & Medicinal Chemistry Letters, v.23, no.5, pp.1193 - 1196 Bioorganic & Medicinal Chemistry Letters 23 5 1193 1196 scie scopus 000314693400006 2-s2.0-84873727335 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article IN-VITRO ACTIVITY IDENTIFICATION Oxazolidinone Antibiotics Synthesis Antibacterial activity