D'Souza, Shilpa Park, Seung-Yoon Kim, In-San 2024-01-20T13:00:13Z 2024-01-20T13:00:13Z 2022-01-10 2013-03 0006-291X https://pubs.kist.re.kr/handle/201004/128280 Phosphatidylserine (PS) exposed by necrotic cells serves as an engulfment signal for their effective clearance. However, the molecular mechanism responsible for the PS-dependent clearance of necrotic cells remains to be investigated. Here, we show that stabilin-2 acts as a receptor for necrotic cell clearance. Stabilin-2-mediated necrotic cell engulfment occurred in a PS-dependent manner. EGF-like domain repeat (a PS-recognition domain of stabilin-2) bound to necrotic cells and inhibited the stabilin-2-mediated engulfment. However, primary necrotic cells did not induce the anti-inflammatory effect in stabilin-2-expressing cells. These findings facilitate the elucidation of the molecular mechanisms responsible for the PS-dependent clearance of necrotic cells. (C) 2013 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE Stabilin-2 acts as an engulfment receptor for the phosphatidylserine-dependent clearance of primary necrotic cells Article 10.1016/j.bbrc.2013.01.133 1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.432, no.3, pp.412 - 417 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 432 3 412 417 N scie scopus 000316843200003 2-s2.0-84874982509 Biochemistry & Molecular Biology Biophysics Biochemistry & Molecular Biology Biophysics Article HYALURONAN RECEPTOR PHAGOCYTOSIS MACROPHAGES RECOGNITION INTEGRIN CORPSES FEEL-1 DEATH Phagocytosis Necrotic cells Phosphatidylserine Stabilin-2