Butler, Shannon M. Wallig, Matthew A. Nho, Chu Won Pan, Cheol-Ho Lee, Eun-Ha Jung, Sang Hoon Jeffery, Elizabeth H. 2024-01-20T13:00:28Z 2024-01-20T13:00:28Z 2021-09-01 2013-03 0278-6915 https://pubs.kist.re.kr/handle/201004/128293 Gymnaster koraiensis (GK) is a Korean herb used in folk medicine and recently found to positively impact liver health. Because GK contains polyacetylenes and because other polyacetylenes have been found to exhibit anti-inflammatory and anti-cancer activities, we hypothesized that the polyacetylene gymnasterkoreayne B (GKB), known to increase hepatic detoxification enzymes, may also exert anti-inflammatory and anti-cancer activities. We fed male C57BL/6 mice purified AIN93G diets containing no additions, GKB or the GKB-rich fraction of an ethanol extract (GE) from GK to determine if these diets would slow or prevent either inflammation or inflammation-enhanced colon cancer, using the dextran sulfate sodium/azoxymethane mouse model. The GKB (500 mu mol/kg diet daily) showed some anti-inflammatory activity, but GE, containing an equal dose of GKB, protected strongly against both inflammation and colon cancer, decreasing adenocarcinomas by 90%. These data support further research into GK as a promising potential anti-cancer agent. (C) 2012 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD BIOACTIVITY INDUCTION A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice Article 10.1016/j.fct.2012.11.049 1 FOOD AND CHEMICAL TOXICOLOGY, v.53, pp.235 - 239 FOOD AND CHEMICAL TOXICOLOGY 53 235 239 scie scopus 000322924700033 2-s2.0-84871970447 Food Science & Technology Toxicology Food Science & Technology Toxicology Article BIOACTIVITY INDUCTION Azoxymethane Colon cancer Dextran sulfate sodium Prevention Inflammation Polyacetylene