Hayat, Faisal Yoo, Euna Rhim, Hyewhon Choo, Hea-Young Park 2024-01-20T13:02:07Z 2024-01-20T13:02:07Z 2022-01-25 2013-02 0253-2964 https://pubs.kist.re.kr/handle/201004/128375 A novel series of aryl sulfonylpiperazine derivatives (5-15) were synthesized as 5-HT6 ligands. In vitro assay was evaluated by measuring the 5-HT-induced Ca2+ increases using HeLa cell line expressing the cloned human 5-HT6 receptor, and the compound 13 showed potent 5-HT6 receptor antagonistic effect with IC50 value of 3.9 mu M. Compound 13 also showed good selectivity on the 5-HT6 over 5-HT4 and 5-HT7 receptors. English KOREAN CHEMICAL SOC Synthesis and Inhibition Effects on 5-HT6 Receptor of Benzothiazole Derivatives Article 10.5012/bkcs.2013.34.2.495 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.2, pp.495 - 499 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 34 2 495 499 N scie scopus kci 000316430200031 2-s2.0-84874525087 Chemistry, Multidisciplinary Chemistry Article CENTRAL-NERVOUS-SYSTEM SEROTONIN RECEPTOR MOLECULAR-CLONING RAT LOCALIZATION ANTAGONISTS LIGANDS PHARMACOLOGY MUTAGENESIS PROGRESS Sulfonamide N-Methyl piperazine 5-HT6 receptor antagonist