Cho, Sung Youn Chae, Soo-Won Choi, Kui Won Seok, Hyun Kwang Kim, Yu Chan Jung, Jae Young Yang, Seok Jo Kwon, Gyeong Je Kim, Jong Tack Assad, Michel 2024-01-20T13:02:43Z 2024-01-20T13:02:43Z 2021-09-01 2013-02 1552-4973 https://pubs.kist.re.kr/handle/201004/128406 The biocompatibility and strength retention of a Mg-Ca-Zn alloy were studied to evaluate its efficacy for osteosynthesis applications. Mg-Ca-Zn alloy and self-reinforced poly l-lactide (SR-PLLA) bone screws were implanted into New Zealand rabbits for radiography analysis, micro computed tomography analysis, histomorphometry, hematology, serum biochemistry, histopathology, and inductively coupled plasma mass spectrometry analysis. Bending and torsion tests were performed on intact specimens to find the initial mechanical strength of these Mg-Ca-Zn alloy bone screws. Strength retention of the Mg-Ca-Zn alloy implants were calculated from in vivo degradation rates and initial mechanical strength. Based on the animal study, Mg-Ca-Zn alloy bone screw showed absence of subcutaneous gas pockets, characteristic surface erosion properties, faster degradation rate than SR-PLLA bone screw, normal reference range of hematology and serum biochemistry, better histopathological response than SR-PLLA bone screw, and stable concentrations of each constituent element in soft tissues surrounding the implants. The initial strength and strength retention of Mg-Ca-Zn alloy were compared with those of various biomaterials. The initial strength of Mg-Ca-Zn alloy was higher than those of biostable and biodegradable polymers. The strength retention of Mg-Ca-Zn alloy bone screws was similar to those of biodegradable polymer. Therefore, this Mg-Ca-Zn alloy represents an excellent biodegradable biomaterial candidate for osteosynthesis applications. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013. English WILEY-BLACKWELL IN-VIVO CORROSION MAGNESIUM ALLOYS MECHANICAL-PROPERTIES INTERNAL-FIXATION COMPOSITE RODS RABBIT POLYMERS PART BIOMATERIALS SCREWS Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants Article 10.1002/jbm.b.32813 1 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v.101B, no.2, pp.201 - 212 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 101B 2 201 212 scie scopus 000313348400001 2-s2.0-84879315746 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article POLYMERS PART BIOMATERIALS SCREWS IN-VIVO CORROSION MAGNESIUM ALLOYS MECHANICAL-PROPERTIES INTERNAL-FIXATION COMPOSITE RODS RABBIT biodegradation biodegradable metal absorbable bone screw magnesium