Joung, Yoon Ki Jang, Ji Young Choi, Jong Hoon Han, Dong Keun Park, Ki Dong 2024-01-20T13:03:03Z 2024-01-20T13:03:03Z 2021-09-01 2013-02 1543-8384 https://pubs.kist.re.kr/handle/201004/128424 Combination chemotherapy using more than two therapeutic agents with different modes of action is a promising strategy that can be used to enhance the therapeutic efficacy of cancer treatment, even though it is a complicated treatment modality. The aim of this study was to investigate how a novel multidrug nanocarrier is effective for combination chemotherapy in vitro and, more specifically, whether combined agents with different modes of action and physicochemical properties show synergistic cytotoxicity with the use of this nanocarrier. A heparin-Pluronic (Hep-Pr) nanogel encapsulating both paclitaxel and DNase was shown to be efficient for intracellular delivery with respect to size, encapsulation efficiency, and intracellular uptake/fates. As a result of these properties, a Hep-Pr nanogel combined with paclitaxel and DNase exhibited a dose-dependent synergistic cytotoxicity compared to single drug and free-drug treatments, whose combination indices were 0.93 and 0.45 at higher concentrations (250 and 500 mu g/mL). Therefore, Hep-Pr nanogels have the potential to deliver multitherapeutic agents with different characteristics and thereby enhance the therapeutic efficacy of combination cancer chemotherapy. English AMER CHEMICAL SOC DOXORUBICIN PACLITAXEL MECHANISM MICELLES DELIVERY CANCER DNASE Heparin-Conjugated Pluronic Nanogels as Muiti-Drug Nanocarriers for Combination Chemotherapy Article 10.1021/mp300480v 1 MOLECULAR PHARMACEUTICS, v.10, no.2, pp.685 - 693 MOLECULAR PHARMACEUTICS 10 2 685 693 scie scopus 000314627400027 2-s2.0-84873399931 Medicine, Research & Experimental Pharmacology & Pharmacy Research & Experimental Medicine Pharmacology & Pharmacy Article DOXORUBICIN PACLITAXEL MECHANISM MICELLES DELIVERY CANCER DNASE heparin Pluronic combination chemotherapy DNase paclitaxel nanocarrier