Ermakova, Svetlana Men'shova, Roza Vishchuk, Olesya Kim, Sang-Min Um, Byung-Hun Isakov, Vladimir Zvyagintseva, Tatyana 2024-01-20T13:04:40Z 2024-01-20T13:04:40Z 2021-09-01 2013-01 2211-9264 https://pubs.kist.re.kr/handle/201004/128505 Water-soluble polysaccharides were isolated from the brown alga Eisenia bicyclis, which was collected near the coast of the Republic of Korea. The structures of laminaran and fucoidan were investigated. Laminaran from E. bicyclis was determined to be a glucan with beta-(1 -> 6) side chains linked to a beta-(1 -> 3) backbone with relatively few branch points. Based on nuclear magnetic resonance (NMR) data, the ratio of the beta-(1 -> 3) and beta-(1 -> 6) linkages was estimated as 2.6:1. Fucoidan from E. bicyclis was found to contain 1,3-linked fucose residues, some 1,6-, 1,2,6-, 1,4,6-linked galactose residues and traces of mannose and xylose. In addition, the amount of sulfate in fucoidan was 13.2%. Those polysaccharides were non-cytotoxic to human melanoma SK-MEL-28 and colon cancer DLD-1 cells. Laminaran and fucoidan from E. bicyclis inhibited the colony formation of those cells. Therefore, they may have potential as antitumor agents. (c) 2012 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV FUCOIDAN CELLS LAMINARAN GLUCAN Water-soluble polysaccharides from the brown alga Eisenia bicyclis: Structural characteristics and antitumor activity Article 10.1016/j.algal.2012.10.002 1 ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v.2, no.1, pp.51 - 58 ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 2 1 51 58 scie scopus 000325054700008 2-s2.0-84873097640 Biotechnology & Applied Microbiology Biotechnology & Applied Microbiology Article FUCOIDAN CELLS LAMINARAN GLUCAN Brown alga Laminarans Fucoidans Structure Anticancer activity