Lee, Woojung Park, Soon-Hye Lee, Seungyong Chung, Bong Chul Song, Min Ok Song, Kyung Il Ham, Jungyeob Kim, Su-Nam Kang, Ki Sung 2024-01-20T13:30:33Z 2024-01-20T13:30:33Z 2021-09-05 2012-12-15 0308-8146 https://pubs.kist.re.kr/handle/201004/128542 Ginsenoside Re, one of the major triol type ginsenosides contained in Panax ginseng, has a hydrophobic four-ring steroid-like structure with hydrophilic sugar moieties at carbon-3 and -20. The aim of the present study was to identify the changes in structure and antioxidant activity of ginsenoside Re by the Maillard reaction, which has not been reported yet. The free radical-scavenging activity of ginsenoside Re-alanine mixture was increased by heat-processing. Ginsenoside Re was gradually changed into Rg(2). Rg(6) and F-4 by heat-processing, and the glucosyl moiety at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs). Antioxidant MRPs were generated from the reaction of glucose and alanine. Based on the viability results of LLC-PK1 renal epithelial cells, MRPs and less-polar ginsenosides contributed to the combined renoprotective effect against oxidative renal damage. Maillard reaction is importantly involved in the increased antioxidant effect of ginsenoside by heat-processing. (C) 2012 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD RADICAL-SCAVENGING ACTIVITY ANTIINFLAMMATORY ACTIVITIES REACTION-PRODUCTS OXIDATIVE STRESS DIHYDROCHLORIDE EXTRACT DAMAGE RB-1 TEA Increase in antioxidant effect of ginsenoside Re-alanine mixture by Maillard reaction Article 10.1016/j.foodchem.2012.06.108 1 FOOD CHEMISTRY, v.135, no.4, pp.2430 - 2435 FOOD CHEMISTRY 135 4 2430 2435 scie scopus 000309786400047 2-s2.0-84865317430 Chemistry, Applied Food Science & Technology Nutrition & Dietetics Chemistry Food Science & Technology Nutrition & Dietetics Article RADICAL-SCAVENGING ACTIVITY ANTIINFLAMMATORY ACTIVITIES REACTION-PRODUCTS OXIDATIVE STRESS DIHYDROCHLORIDE EXTRACT DAMAGE RB-1 TEA Ginsenoside Re Panax ginseng Maillard reaction Free radical Heat-processing