Kim, Angela Latchoumane, Charles Lee, Soojung Kim, Guk Bae Cheong, Eunji Augustine, George J. Shin, Hee-Sup 2024-01-20T13:30:42Z 2024-01-20T13:30:42Z 2022-01-10 2012-12-11 0027-8424 https://pubs.kist.re.kr/handle/201004/128550 Sleep spindles are rhythmic patterns of neuronal activity generated within the thalamocortical circuit. Although spindles have been hypothesized to protect sleep by reducing the influence of external stimuli, it remains to be confirmed experimentally whether there is a direct relationship between sleep spindles and the stability of sleep. We have addressed this issue by using in vivo photostimulation of the thalamic reticular nucleus of mice to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles. Such optogenetic generation of sleep spindles increased the duration of non-rapid eye movement (NREM) sleep. Furthermore, the density of sleep spindles was correlated with the amount of NREM sleep. These findings establish a causal relationship between sleep spindles and the stability of NREM sleep, strongly supporting a role for the thalamocortical circuit in sleep regulation. English NATL ACAD SCIENCES THALAMIC RETICULAR NUCLEUS LESS-THAN-1 HZ OSCILLATION CALCIUM-CHANNEL NEURONS STATES MODES WAVES BURST Optogenetically induced sleep spindle rhythms alter sleep architectures in mice Article 10.1073/pnas.1217897109 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.50, pp.20673 - 20678 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109 50 20673 20678 scie scopus 000312605600105 2-s2.0-84874436363 Multidisciplinary Sciences Science & Technology - Other Topics Article THALAMIC RETICULAR NUCLEUS LESS-THAN-1 HZ OSCILLATION CALCIUM-CHANNEL NEURONS STATES MODES WAVES BURST sleep rhythms sleep protection