서성호 강성남 박상민 최지연 정윤기 김익환 한동근 2024-01-20T13:31:18Z 2024-01-20T13:31:18Z 2021-09-06 2012-12 1226-4601 https://pubs.kist.re.kr/handle/201004/128581 Biodegradable polymers have been used to develop cardiovascular prostheses such as vascular grafts and stents. However,thrombosis, inflammation, and restenosis that are associated with implants are still major obstacles for the use of these devices. The lack of endothelial cell (EC) lining (endothelialization) and the response of immune systems to the stents have been associated with these complications. In addition, several clinical studies have focused on the early markers or initiators of the inflammatory response in coronary stenting. The clinical reports demonstrated that some inflammatory markers, C-reactive protein (CRP), interlukin-6 (IL-6), and interlukin-1 (IL-1) exhibited relative rise in 10minutes after inserting stent. Therefore, we have examined the cell viability and the expression levels of IL-6 after treating smooth muscle cell (SMC) with the degradation product of poly(L-lactide) (PLLA) and poly(D,L-lactide-co-glycolide)(PLGA) containing sirolimus (SRL) drug. Korean 한국생체재료학회 심혈관계 이식물용 생분해성 고분자의 세포 독성 및 급성 염증반응 Cell Toxicity and Acute Inflammatory Response of Biodegradable Polymers for Cardiovascular Implants Article 2 생체재료학회지, v.16, no.4, pp.171 - 176 생체재료학회지 16 4 171 176 kci ART001717986 cell toxicity inflammation biodegradable polymers smooth muscle cell drug-eluting stent